Abstract：Abstract： A multi-channel real-time system is designed for monitoring photoplethysmographic (PPG) using RISC-V kernel. The system takes E203 IP of RISC-V architecture as the low-power core, which connects analog front-end module and Bluetooth control module through ICB bus. The analog front-end control module controls back-to-back LEDs to realize two-channel PPG signal acquisition. Multi-channel acquisition can be realized by reusing the analog front-end control module. The Bluetooth control module is connected to E203 to deliver system control commands, and then upload PPG data to the terminal. Finally, The FPGA system verifies the 22-bit dual-channel PPG signal Internet of Things terminal application.

Abstract：Abstract： Cell traction force microscopy method is one of the mainstream tools for measuring cell traction force, which uses fluorescent microbeads as markers to measure the deformation of the substrate and calculate cell traction force. However, due to the random distribution of fluorescent microbeads in the substrate, the calculation accuracy of the cell traction force field maybe affected. To address the problem of uncontrollable depth of fluorescent microbeads, a method using patterned elastic substrate was proposed to measure cell traction forces, in which the micropattern arrays fabricated on the surface of substrate was used as deformation markers. A micro-pad array with diameter of 3 µm and height of 0.8 µm was designed and fabricated on the polydimethylsiloxane substrate surface as the displacement markers. In the finite element simulation, external forces mimicking cell traction forces was applied at different locations on the substrate surface and the displacements field of the micro-pad array was obtained. Using the displacements field obtained by simulation, the traction force field was calculated through the traction force inversion algorithm, and the results were consistent with the input external forces in the simulation. The patterned elastic substrates were validated by mapping neonatal rat ventricular myocytes contraction forces. Both simulation and experiment demonstrate that the capacity of patterned elastic substrate for generating accurate cell contraction force maps, providing new research method for pathological study of myocardial diseases.

Abstract：Abstract： The assessment of coagulation can help diagnose blood diseases, guide treatment of cardiovascular diseases, and assess risk of bleeding during surgery. Physical coagulation testing is of great interest to clinical medicine because of its short detection time, high sensitivity, and simple operation. With the rapid development of optical coherence tomography (OCT) technology, it has been used in the blood coagulation detection. In this paper, we summarize the physical methods for the blood coagulation detection in recent years and specially review the applications of the OCT methods in the coagulation testing. The future development of blood coagulation detection is also prospected.

Abstract： Resonant microcantilever is a mass-type sensor that transforms mass change into frequency-shift signals. Due to the advantages of high mass resolution, high sensitivity, low cost, easy integration and miniaturization, resonant microcantilevers have received extensive attention from researchers. In recent years, with the rapid development of MEMS (Micro-Electro-Mechanical Systems) technology, resonant micro-cantilever sensors have been widely used in mass and flow control, trace biomedical detection, gas or liquid molecular analysis and other broad application fields. Herein, the specific applications of resonant microcantilever sensors in environmental detection, biomedicine and other fields in recent years are reviewed, and the future development trends are prospected.

Abstract：Volatile Organic Compounds (VOCs) are not only present in the human living conditions, but also can be produced in the process of human metabolism. The types and kurtosis of VOCs produced by the human body are closely related to human health and disease status. In recent years, analyzing VOCs components and concentration in human exhaled breath through non-invasive detection can be used to indicate human health status, which has been widely concerned in the field of clinical diagnosis and health monitoring. This paper reviews the clinical application value and common detection methods of exhaled VOCs, and elucidates pros and cons of each method . In this paper, the revolutionary progress brought by the new electronic nose technology to the detection of exhaled VOCs is described, which brings more possibilities for the high sensitivity, high throughput and intelligent detection of exhaled VOCs.